Pair Name	Costunolide, Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
In Vivo Model	PC-3 cells (3×10⁶) were injected subcutaneously into the armpit of each mouse.
Result	We suggested that costunolide in combination with doxorubicin was a new potential chemotherapeutic strategy for treating prostate cancer.

Pair Name	Costunolide, Doxorubicin
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	K-562	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0004
Result	These results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia.